Hair polynucleotide injections in Paris

Dermato Aesthetic Clinic – Paris, 16rd

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Polynucleotides are an innovative injectable treatment used to stimulate hair regrowth. Through their regenerative action on the scalp, they create an environment conducive to the revitalization of hair follicles. This treatment works deep down to improve scalp quality, boost microcirculation, and reactivate stem cells involved in hair growth.

FromHighly purified salmon DNA, the polynucleotides used at the Renécia Clinic, are powerful biostimulators. Unlike a classic topical treatment, they are injected directly into the dermis of the scalp to act as close as possible to the bulbs.

This hair treatment is suitable for both women and men, in cases of diffuse hair loss, thinning areas, or as a supportive treatment after a hair transplant.

What is a Polynucleotide Hair Injection?

Polynucleotides (PN or PN-HPT™) are naturally occurring DNA fragments used in regenerative medicine to stimulate hair regrowth. Derived from highly purified salmon DNA, they are composed of long chains of nucleotides, the building blocks of our DNA, capable of deeply activating cellular repair and renewal mechanisms.

Injected into the dermis of the scalp, polynucleotides exert several beneficial actions:

  • They reactivate hair follicle stem cells
  • They improve local microcirculation
  • They stimulate an environment favorable to hair growth
  • They restore the balance of the scalp
  • They strengthen the vascularization around the bulbs

Unlike other injectable treatments that only provide nutrients or cosmetic active ingredients, PNs act in depth action on the cells of the scalp, causing a lasting biological recovery regrowth, even in areas that have been bald for several months.

Their safety is well established, with over 70 years of research, excellent clinical tolerance, and numerous published studies. At Clinique Renécia, we use PhilArt Hair™ hair polynucleotides, a new generation injectable solution developed by Croma-Pharma, specifically formulated to stimulate follicular activity.

Who is a polynucleotide injection for?

Polynucleotide hair treatment is for people who want to stimulate hair regrowth in a natural and lasting way, without resorting to hormonal or invasive treatments. Thanks to their trophic action on the scalp, polynucleotides allow reactivate the follicles and to optimize the quality of the capillary terrain.

This treatment is recommended for both women and men, at all stages of density loss, including areas that have been thinning for a long time. It is also indicated in post-hair transplant, to accelerate regrowth and promote graft take.

Main indications:

  • Diffuse density loss
  • Thinning or receding hairline
  • Slow regrowth or thinning hair
  • Devitalized or unbalanced scalp
  • Prevention or support of treatments against hair loss
  • Regular maintenance of hair capital
  • Adjuvant treatment after hair transplantation
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How is a polynucleotide injection performed?

Before the session

A medical consultation is essential before beginning treatment. The practitioner will assess the condition of your scalp, hair density, and your medical history. A personalized treatment plan will be developed based on your situation (thinning areas, post-transplant regrowth, overall maintenance, etc.).

During the session

The treatment is based on PhilArt Hair, a polynucleotide-based hair biostimulator, developed by the Croma-Pharma laboratory. This injectable product acts directly on the scalp to:

  • Stimulate the activity of hair follicle stem cells,
  • Promote local microcirculation,
  • Create an environment conducive to regrowth,
  • Deeply rehydrate and revitalize.

PhilArt Hair is packaged in pre-filled syringes, containing 15 mg of highly purified polynucleotides (PN-HPT™). The product is injected into microdroplets intradermal, using a very fine needle. An anesthetic cream may be applied beforehand for greater comfort.

After the session

Localized redness or slight discomfort may appear on the scalp, but this generally disappears within a few hours. It is possible to resume activities immediately after treatment, provided that certain precautions are followed for 24 to 48 hours:

  • Avoid harsh shampoos or irritating styling products,
  • Avoid prolonged sun exposure,
  • Avoid saunas, steam rooms or intense sporting activities.

Treatment protocol

  • 3 sessions spaced 4 weeks apart,
  • Then 1 maintenance session every 6 to 12 months, as needed.

polynucleotide injection technique

The treatment is based on the injection of PhilArt Hair, a hair biostimulator developed by Croma-Pharma, specifically formulated based on highly purified polynucleotides (PN-HPT™ technology). These polynucleotides are naturally occurring DNA fragments, derived from the PDRN (polydeoxyribonucleotide), known for their powerful regenerative properties.

What are polynucleotides?

Polynucleotides used in aesthetic medicine should not be confused with polydioxanone (PDO) tensioning threads. Here, they are long chains of nucleotides, the building blocks of DNA, capable of:

  • Stimulate cell proliferation, including scalp support cells (fibroblasts, keratinocytes),
  • Promote local microvascularization, essential for the nutrition of hair follicles,
  • Improve tissue quality, by strengthening the structure of the dermis and scalp,
  • Create a favorable bioactive environment to hair regrowth.

These molecules act as true biological messengers: they send signals of repair and regeneration, allowing the reactivation of follicles in the dormant phase and actively supporting the growth of new hair.

The injection technique 

PhilArt Hair is injected using very fine microneedles, using the intradermal microdroplet technique. The injections are distributed evenly over sparse areas of the scalp: temples, forehead, crown of the head, or diffuse areas. The procedure is relatively painless and can be preceded by local anesthesia if necessary.

This treatment is non-volumizing and perfectly tolerated: it does not alter the texture of the scalp or its immediate external appearance. It acts gradually, stimulating the natural processes of regeneration and growth.

Recommended protocol

  • 3 sessions spaced 4 weeks apart
  • 1 maintenance session every 6 to 12 months

Visible results in hair density, thickness, and quality appear primarily at the end of a full hair growth cycle, typically 3 to 6 months after treatment begins. This time frame is the time it takes for stimulated follicles to enter the active growth phase and produce stronger, thicker, and visibly healthier hair.

What areas can be treated with a polynucleotide injection?

Polynucleotide treatment is suitable for all areas of the scalp where hair quality is impaired, whether due to thinning, loss of density, or moderate hair loss. It can be applied in a targeted or more widespread manner depending on the specific needs of each patient.

The main areas concerned are:
• The frontal line, often affected first, especially in men, where regrowth can be stimulated.
• The temples, which can lighten with age or under stress.
• The top of the skull (vertex), an area frequently affected in cases of androgenetic alopecia.
• The parietal and occipital areas, in case of diffuse thinning of the hair.
• The entire scalp, in cases of diffuse hair loss, telogen effluvium, or to improve the overall health of the scalp and hair quality.

This treatment is suitable for both men and women and can be personalized according to the objectives:

  • Stimulate the growth of new hair,
  • Increase the density of sparse areas,
  • Improve the vitality and health of the scalp,
  • Promote stronger regrowth and thicker hair.

What results can be expected from a polynucleotide injection into hair?

Polynucleotide injections work deep within the scalp to stimulate scalp regeneration and strengthen hair quality. The first effects can sometimes be seen after a few weeks, in the form of improved scalp vitality and a feeling of stronger hair.

However, visible and lasting results require respecting the hair's natural cycle, which generally lasts several months (between 3 and 6 months depending on the cycle phases). It is only after a complete cycle that a notable improvement in hair density is observed, with thicker, stronger, and healthier hair.

Over the long term, polynucleotides promote cell regeneration, improve scalp vascularization, and strengthen hair follicles. This treatment helps support natural, long-lasting hair regrowth while improving overall hair quality.

This approach is ideal for those who want to stimulate growth, thicken thinning areas, and improve overall scalp health in a gradual and natural way.

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Indications and contraindications for polynucleotide injections

Polynucleotide treatment is primarily intended for people wishing to stimulate hair regrowth in cases of moderate hair loss. It also helps strengthen the vitality and quality of the scalp, thus improving the environment necessary for hair growth. This treatment promotes increased density and thickness of thinning hair, while also helping to treat certain scalp disorders linked to weakened hair follicles.

Contraindications

  • Presence of active infectious or inflammatory lesions on the scalp,
  • Known allergy to one of the components of the injected product,
  • Alopecia at too advanced a stage where treatment would be ineffective,
  • Bleeding disorders or taking anticoagulants,
  • Chronic, progressive or severe skin disorders,
  • Hypersensitivity to hyaluronic acid (in case of combined treatment),
  • Autoimmune diseases,
  • Pregnancy and breastfeeding (as a precautionary measure).

A prior discussion with the doctor is essential to assess the compatibility of the treatment and rule out any contraindications.

Combination care for hair loss

At Clinique Renécia, each treatment is personalized based on your type of alopecia, age, medical history, and goals. To achieve the best results, we favor a combined approach.
Treatment begins with dutasteride mesotherapy, which works directly at the root to stop hair loss. This step is essential to stop the progression of alopecia.
To stimulate regrowth and improve hair quality, we combine this treatment with a specific treatment, chosen according to the sensitivity of your scalp and your profile: this can be exosomes, polynucleotides (PDRN) or the Keralase treatment, depending on your case.
Each protocol is tailor-made, guaranteeing effective treatment without social exclusion.
In some cases where the combination of dutasteride plus hair stimulant is not enough, we supplement the treatment with intramuscular injections of Biotin Bepanthen, which directly strengthen and support hair metabolism, thus promoting better growth and overall hair health.

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Price of a polynucleotide injection session

Polynucleotide injection

€300

Please note: The recommended protocol is 3 sessions at 4-week intervals, followed by maintenance every 6 to 12 months.

Hair polynucleotide injection Paris

Are you interested in hair polynucleotide injections in Paris and would like to know more about this treatment?

Make an appointment with a doctor at our dermato-aesthetic clinic to obtain more information and discuss a possible procedure.

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faq

Polynucleotides are natural molecules composed of long chains of DNA or RNA, used in aesthetic medicine to stimulate cell regeneration. Injected into the scalp, they promote hair follicle repair, improve scalp quality, and stimulate the production of collagen and elastin, essential for healthy hair.

Polynucleotide treatment is suitable for men and women suffering from moderate hair loss, those with a weakened scalp or weakened hair follicles. It is indicated to improve hair density, vitality and quality, as a complement or alternative to other hair treatments.

After a consultation with a scalp specialist, the area to be treated is disinfected. The product is then injected into the scalp using fine microneedles in small amounts in a precise grid pattern. The session generally lasts between 20 and 30 minutes.

A course of 3 sessions spaced one month apart is usually recommended, followed by a maintenance session every 6 to 12 months depending on the results obtained. The effects begin to appear gradually, but optimal results often appear after several months, in line with the natural hair growth cycle.

Yes, it is often recommended to combine polynucleotides with other treatments such as dutasteride mesotherapy to slow hair loss, or revitalizing treatments to maximize results.

The first signs of improvement can be noticeable as early as one month, but it usually takes several months, often at least 3 to 6 months, to see significant results, due to the natural hair growth cycle.

After the initial treatment, regular follow-up and maintenance sessions may be offered to stabilize regrowth and preserve scalp health according to individual needs.

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