Polynucleotide injection Paris

Dermato Aesthetic Clinic – Paris, 16^rd

Polynucleotides are an injectable treatment used in aesthetic medicine to improve skin quality. Their purpose is to deeply hydrate the skin, stimulate collagen production, and help regenerate cells. This makes the skin firmer, more elastic, and brighter.

Unlike hyaluronic acid, which is used to restore volume, polynucleotides work on the deep structure of the skin. They correct small spots, smooth irregularities, and repair damaged tissue. This treatment is made from highly purified salmon DNA, making it natural and effective. Long used in medicine, they promote the creation of new small blood vessels, strengthen the skin, and reduce spots for a more radiant and even complexion.

What is a Polynucleotide facial injection?

Polynucleotides are naturally occurring DNA fragments used in aesthetic medicine to improve skin quality. These long chains of nucleotides, the building blocks of our DNA, act by stimulating fibroblasts, the cells responsible for the production of collagen and elastin.

Injected into the dermis, polynucleotides promote:

Cellular regeneration
The production of collagen and elastin
Improving skin hydration
Repair of damaged tissues
Reduction of hyperpigmentation
Neutralization of free radicals

Unlike hyaluronic acid, which acts on volume and immediate hydration, NPs act deep down, on the structure and function of the skin. The result is smoother, firmer, more even, and visibly revitalized skin.

Their excellent tolerance and safety are well established, with more than 70 years of research and more than 100 published studies presented at national and international conferences.

Who is a polynucleotide injection for?

Polynucleotide injections is for patients who want to visibly improve the quality of their skin naturally, without adding volume or changing features. It is particularly suitable for fragile, marked skin or skin that has lost its tone.

Main indications

Wrinkles and fine lines
Loss of firmness
Thin, dry or dehydrated skin
Dull or tired complexion
Hyperpigmentation (brown spots, uneven skin tone)
Rosacea and diffuse redness
Acne scars or skin changes
Skin aging of the face, neck, décolleté or hands

How is a polynucleotide injection performed?

Before the session

A medical consultation is essential before any treatment. The practitioner assesses the condition of your skin and your medical history, and determines the indications suited to your needs (wrinkles, sagging, dark circles, scars, etc.). A personalized treatment plan is then established, specifying the number of sessions potentially required.

During the session

The treatment is based on the use of PhilArt, an innovative biostimulator developed by Croma-Pharma. This injectable gel is composed of long-chain polynucleotides, which create an optimal environment to stimulate collagen production, promote skin hydration and neutralize free radicals.

PhilArt comes in the form of a soft gel, injected directly into the medium to deep dermisIt can be administered in different ways depending on the area being treated:

in micro-droplets,
linear,
with a very fine needle or an cannula.

For added comfort, a numbing cream can be applied before injection.

After the session

Redness, slight swelling or small bruises may appear in the following hours, but they disappear quickly.
You can resume your activities as soon as you leave the office, taking a few precautions for 24 to 48 hours:

Avoid makeup,
Avoid sun exposure,
Avoid intense sporting activities or heat sources (sauna, hammam).

For optimal results, it is recommended to carry out:

As a preventative treatment, for younger skin:

A treatment of 3 sessions every 3 weeks
Maintenance sessions every 2 to 3 months

Repairing treatment, a more intense treatment for mature skin:

A treatment of 4 sessions every 1 to 2 weeks
Maintenance sessions every 1 to 3 months

For both options, the technique used is intradermal injection using the microdroplet technique or the linear retrograde technique.
This progressive treatment acts in depth to sustainably improve skin quality et stimulate its natural regeneration.

polynucleotide injection technique

The treatment is based on the injection of PhilArt de Croma-Pharma, an innovative biostimulator formulated based on highly purified polynucleotides (PN-HPT technology). This injectable gel is specifically designed to improve skin quality, particularly in delicate areas such as the eye area, forehead, neck, hands and even scars (especially acne scars).

Polynucleotides are injected into the mid to deep dermis using very fine microneedles or cannulas, using different techniques: microdroplets, linear or fan-shaped.

Unlike hyaluronic acid, this treatment does not add volume, which allows it to treat thin and mobile areas such as the eyelids or upper lip, without the risk of an oversized effect. It works by deeply hydrating, neutralizing free radicals, and creating an environment favorable to tissue regeneration, in particular by stimulating fibroblasts (production of collagen and elastin).

The recommended protocol is 3 sessions at 4-week intervals, followed by maintenance every 6 to 12 months. Results are gradual, with visible improvements in skin elasticity, texture, and radiance, while remaining very natural.

What areas can be treated with a polynucleotide injection?

Polynucleotide treatment is suitable for a wide variety of areas and needs, both on young skin that on mature skin.

Entire face, including forehead and cheekbones
Neck, décolleté and hands: Thanks to its biostimulant and restorative properties.

This treatment acts in a targeted manner, while remaining very natural, without creating artificial volume.

What results can be expected from a polynucleotide injection?

The results of polynucleotide injections are progressive, natural and long-lasting. From the first sessions, we observe:

More hydrated, supple and luminous skin
A clear improvement in skin texture: smoother skin, refined texture
A visible reduction in fine lines and wrinkles, especially around the eyes
Firmer and more elastic skin
A refreshed and revitalized look
An overall “healthy glow” effect, without added volume or frozen effect

In the long term, polynucleotides stimulate fibroblast activity and promote the natural production of collagen and elastin. This allows for deep skin regeneration, with visible results up to 6 to 8 months after the initial treatment.

This treatment, administered alone, aims to improve the quality and texture of the skin in younger patients as an anti-aging (or preventative) treatment. In older patients, it aims to strengthen the structure and general elasticity of the skin as well as to remodel areas of the skin with high fiber density (stretch marks and scars).

Indications and contraindications for polynucleotide injections

Polynucleotide treatment is indicated for:

Hydrate and revitalize young or dehydrated skin
Reduce fine lines and improve skin texture (forehead, eye area, neck, hands)
Treat scars, especially acne scars
Restore firmness, suppleness and radiance to weakened areas (face, décolleté, wrists)
Reduce dark circles, smooth lower eyelids and redensify the look
Stimulate hair regrowth in cases of moderate hair loss, on the scalp and eyebrows

As with any aesthetic procedure, certain situations exclude the use of polynucleotides:

Active local infectious or inflammatory lesions
Known allergy to one of the components of the injected product
Alopecia at too advanced a stage (treatment would then be ineffective)
Bleeding disorders or taking blood thinners
Chronic, progressive or severe skin disorders
Hypersensitivity to hyaluronic acid (in case of combination with non-crosslinked acid)
Autoimmune diseases
Pregnancy and breastfeeding (as a precautionary measure)

New generation injectable care

In facial aesthetics, the most well-known treatments for reshaping or rejuvenating the skin are botulinum toxin (more commonly known as Botox) and hyaluronic acid. These two solutions are primarily used to smooth wrinkles or restore volume to certain areas of the face.

Recently, four new alternatives have emerged to provide deep, long-lasting hydration to the skin, without adding volume. These treatments provide 100% natural results by improving the quality and firmness of the skin:

Polynucleotides :
- Intensely hydrate and stimulate cell regeneration.
- Improve skin texture and firmness.
- Repair damaged tissue and correct irregularities.
- Ideal for revitalizing tired and dull skin.
Skinboosters :
- Based on hyaluronic acid, but at low concentration.
- Provide deep and long-lasting hydration by stimulating the skin's natural production of hyaluronic acid.
- Improve elasticity and suppleness.
- Perfect for adding radiance to the face without changing volume.
The Profhilo :
- Injection of very pure and fluid hyaluronic acid.
- Strongly stimulates the production of collagen and elastin.
- Improves firmness and elasticity, and subtly plumps the skin.
- Targets overall skin quality more than wrinkles or volumes.
The Sculptra :
- Contains poly-L-lactic acid which stimulates natural collagen production.
- Induces a progressive and lasting lifting effect.
- Does not give immediate volume, but natural remodeling in the medium term.
- Suitable for sagging skin with loss of density.

Each of these treatments works differently, but all share the common goal of deeply hydrating, firming and revitalizing the skin, with a natural appearance and no visible change in volume.

Price of a polynucleotide injection session

Polynucleotide injection

330€ (1 bulb)

Please note: The recommended protocol is 3 sessions at 4-week intervals, followed by maintenance every 6 to 12 months.